Small Intestinal Bacterial Overgrowth/SIBO Testing (Cyrex Labs Array 22)


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Irritable bowel syndrome is a chronic functional gut health issue that is difficult to diagnose because conventional methods of testing for the underlying cause of abdominal discomfort such as endoscopy, MRI, CT Scan, and Ultrasound only look for structural (not functional) abnormalities. For this reason, many individuals with IBS suffer in silence or are told that their health condition is caused by depression or some other mental health issue.

Irritable bowel syndrome is often triggered by a gut infection with bacteria such as E. coli, Salmonella, Shigella, and Campylobacter jejuni. These organisms produce cytolethal distending toxins that can disrupt the tight junctions of the gut. Long after the actual infection is gone, low-grade inflammation and altered intestinal permeability (“leaky gut”) can occur. Up to 70% of IBS patients may also experience fibromyalgia, chronic fatigue, mood disorders, and migraine headaches as a result of low-grade inflammation and leaky gut.

SIBO is defined as the overgrowth of bacteria in the small intestine that are supposed to only reside in the colon. The symptoms of SIBO and IBS overlap, and untreated IBS can often develop into SIBO.

Antibodies against bacterial toxins can cross-react with human cytoskeletal proteins, causing the release of these proteins from epithelial cells. IgA, IgG, and IgM antibodies against bacterial toxins and cytoskeletal proteins can be detected in the blood with high accuracy and reproducibility. This means that SIBO can trigger the development of extra-intestinal autoimmune conditions if left untreated.

Cyrex Array 22 tests for bacterial cytotoxins and cytoskeletal proteins in the bloodstream. This is a much more reliable way of testing for IBS and SIBO than the lactulose hydrogen breath test (too many false positives) and the glucose hydrogen breath test (too many false negatives). The Cyrex Array 22 is also less invasive and less costly than the jejunal aspirate test.

Cyrex Array 22 identifies altered gut microbial populations, SIBO, intestinal cell damage, possible celiac disease, and can differentiate between IBS-D and inflammatory bowel disease with diarrhea.

After you place your order for Cyrex Array 22, you will be sent a test kit in the mail. Dr. Jamie or someone from her team will reach out to you to help you find a phlebotomist who can perform a serum blood draw for you. Only a tiny amount of blood is required for the test, and you will mail this blood sample directly to Cyrex Labs for analysis. When your lab test results have been finalized, you’ll receive an email and a phone call from Dr. Jamie to help you understand your results and next steps.


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